https://hdl.handle.net/20.500.12412/2585 2026-05-06T03:58:50Z https://hdl.handle.net/20.500.12412/5697 Multidisciplinary Prehabilitation and Postoperative Rehabilitation for Avoiding Complications in Patients Undergoing Resection of Colon Cancer: Rationale, Design, and Methodology of the ONCOFIT Study Amaro-Gahete, Francisco J.; Jurado, Javier; Cisneros, Andrea; Corres, Pablo; Marmol-Perez, Andrés; Osuna-Prieto, Francisco J.; Fernández-Escabias, Manuel; Salcedo, Estela; Hermán-Sánchez, Natalia; Gahete, Manuel D.; Aparicio, Virginia A.; González-Callejas, Cristina; Mirón Pozo, Benito; Ruiz, Jonatan R.; Nestares, Teresa; Carneiro-Barrera, Almudena ONCOFIT is a randomized clinical trial with a two-arm parallel design aimed at determining the influence of a multidisciplinary Prehabilitation and Postoperative Program (PPP) on post-surgery complications in patients undergoing resection of colon cancer. This intervention will include supervised physical exercise, dietary behavior change, and psychological support comparing its influence to the standard care. Primary and secondary endpoints will be assessed at baseline, at preoperative conditions, at the end of the PPP intervention (after 12 weeks) and 1-year post-surgery, and will include: post-surgery complications (primary endpoint); prolonged hospital length of stay; readmissions and emergency department call within 1-year after surgery; functional capacity; patient reported outcome measures targeted; anthropometry and body composition; clinical/tumor parameters; physical activity levels and sedentariness; dietary habits; other unhealthy habits; sleep quality; and fecal microbiota diversity and composition. Considering the feasibility of the present intervention in a real-life scenario, ONCOFIT will contribute to the standardization of a cost-effective strategy for preventing and improving health-related consequences in patients undergoing resection of colon cancer with an important clinical and economic impact, not only in the scientific community, but also in clinical practice. 2022-11-03T00:00:00Z https://hdl.handle.net/20.500.12412/5696 Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: protocol for the TEMPUS randomised controlled trial Camacho-Cardenosa, Alba; Clavero-Jimeno, Antonio; Martin-Olmedo, Juan J.; Amaro-Gahete, Francisco J.; Cupeiro, Rocío; González Cejudo, María Trinidad; García Pérez, Patricia Virginia; Hernández-Martínez, Carlos; Sevilla Lorente, Raquel; O, Alejandro De-la-; López-Vázquez, Alejandro; Molina-Fernandez, Marcos; Carneiro-Barrera, Almudena; Garcia, Federico; Rodríguez-Nogales, Alba; Gálvez Peralta, Julio Juan; Cabeza, Rafael; Martín-Rodríguez, José L.; Muñoz-Garach, Araceli; Muñoz-Torres, Manuel; Labayen, Idoia; Ruiz, Jonatan R. Introduction Metabolic dysfunction-associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. Implementing strategies based on an intermittent fasting approach and supervised exercise may mitigate the risks. This study aims to investigate the effects of a 12-week time-restricted eating (TRE) intervention combined with a supervised exercise intervention, compared with TRE or supervised exercise alone and with a usual-care control group, on hepatic fat (primary outcome) and cardiometabolic health (secondary outcomes) in adults with obesity. Methods and analysis An anticipated 184 adults with obesity (50% women) will be recruited from Granada (south of Spain) for this parallel-group, randomised controlled trial (TEMPUS). Participants will be randomly designated to usual care, TRE alone, supervised exercise alone or TRE combined with supervised exercise, using a parallel design with a 1:1:1:1 allocation ratio. The TRE and TRE combined with supervised exercise groups will select an 8-hour eating window before the intervention and will maintain it over the intervention. The exercise alone and TRE combined with exercise groups will perform 24 sessions (2 sessions per week+walking intervention) of supervised exercise combining resistance and aerobic high-intensity interval training. All participants will receive nutritional counselling throughout the intervention. The primary outcome is change from baseline to 12 weeks in hepatic fat; secondary outcomes include measures of cardiometabolic health. Ethics and dissemination This study was approved by Granada Provincial Research Ethics Committee (CEI Granada—0365-N- 23). All participants will be asked to provide written informed consent. The findings will be disseminated in scientific journals and at international scientific conferences. 2024-01-24T00:00:00Z https://hdl.handle.net/20.500.12412/5695 Sleep and Anabolic/Catabolic Hormonal Profile in Sedentary Middle-Aged Adults: The FIT-AGEING Study Mochón-Benguigui, Sol; Carneiro-Barrera, Almudena; Dote-Montero, Manuel; Castillo, Manuel J.; Amaro-Gahete, Francisco J. Sleep quality plays an important role in the modulation of several aging markers. This influence could be explained by aging-induced hormonal changes. Indeed, poor sleep quality has been associated with the development of several endocrine-related health complications. This study examined the relationship of both subjective and objective sleep quantity and quality, with basal levels of selected plasma anabolic and catabolic hormones in sedentary middle-aged adults. A total of 74 volunteers (52.7% women; aged 53.7 ± 5.1) were recruited for this study. Subjective sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI; higher scores indicate worse sleep quality), and objective sleep quality parameters (total sleep time [TST], wake after sleep onset [WASO], and sleep efficiency [SE]) were measured using a wrist-worn accelerometer. Basal levels of plasma dehydroepiandrosterone sulphate (DHEAS), total testosterone, sex hormone binding globulin (SHBG), somatotropin, and cortisol levels, were determined. Free testosterone was calculated from the total testosterone and SHBG levels. No associations of global PSQI score, TST, WASO, and SE with DHEAS, free testosterone, and somatotropin plasma levels were found, neither in men nor in women (all p ≥ 0.05). Global PSQI score was inversely related to cortisol plasma levels in women (p = 0.043). WASO was positively associated with cortisol plasma levels, while SE was negatively associated with cortisol plasma levels in women (all p ≤ 0.027). Sleep quality is not related to levels of plasma anabolic hormones, but to levels of catabolic hormones, in sedentary middle-aged adults. Therefore, these results suggest that potential changes in aging biomarkers associated with sleep disturbances, could be mediated by age-related changes in the catabolic endocrine system. 2022-11-25T00:00:00Z https://hdl.handle.net/20.500.12412/5694 Are motivational and self-regulation factors associated with 12 months’ weight regain prevention in the NoHoW study? An analysis of European adults Palmeira, António L.; Marques, Marta M.; Sánchez-Oliva, David; Encantado, Jorge; Santos, Inês; Duarte, Cristiana; Marcela Matos; Carneiro-Barrera, Almudena; Larsen, Sofus C.; Horgan, Graham; Sniehotta, Falko F.; Teixeira, Pedro J.; Stubbs, R. James; Heitmann, Berit L. Purpose Preventing weight regain can only be achieved by sustained changes in energy balance-related behaviors that are associated with weight, such as diet and physical activity. Changes in motivation and self-regulatory skills can support long-term behavioral changes in the context of weight loss maintenance. We propose that experienc‑ ing a supportive climate care is associated with enhanced satisfaction of basic psychological needs, intrinsic goals, and autonomous motivation. These factors are expected to be associate with the utilization of self-regulation skills, leading to more sustained behavior changes and ultimately preventing weight regain. This hypothesis was tested in this ancillary analysis of the NoHoW trial, where the study arms were pooled and followed for 12 months. Methods The NoHoW was a three-center, large-scale weight regain prevention full factorial trial. In this longitudinal study, data were collected in adults who lost>5% weight in the past year (N=870, complete data only, 68.7% female, 44.10±11.86 years, 84.47±17.03 kg) during their participation in a 12-month digital behavior change intervention. Weight and validated measures of motivational- and self-regulatory skills-related variables were collected at baseline, six- and 12 months. Change variables were used in Mplus’ path analytical models informed by NoHoW’s logic model. Results The bivariate correlations confrmed key mediators’ potential efect on weight outcomes in the expected causal direction. The primary analysis showed that a quarter of the variance (r2=23.5%) of weight regain prevention was achieved via the mechanisms of action predicted in the logic model. Specifcally, our results show that supportive climate care is associated with needs satisfaction and intrinsic goal content leading to better weight regain preven‑ tion via improvements in self-regulatory skills and exercise-controlled motivation. The secondary analysis showed that more mechanisms of action are signifcant in participants who regained or maintained their weight. Conclusions These results contribute to a better understanding of the mechanisms of action leading to behavior change in weight regain prevention. The most successful participants used only a few intrinsic motivation-related mechanisms of action, suggesting that habits may have been learned. While developing a digital behavior change intervention, researchers and practitioners should consider creating supportive climate care to improve needs satisfaction and intrinsic goal contents. 2023-10-27T00:00:00Z