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Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T‑cell Acute Lymphoblastic Leukemia

dc.contributor.authorQuaglio, Deborah
dc.contributor.authorZhdanovskaya, Nadezda
dc.contributor.authorTobajas, Gloria
dc.contributor.authorCuartas, Viviana
dc.contributor.authorBalducci, Silvia
dc.contributor.authorChristodoulou, Michael S.
dc.contributor.authorFabrizi, Giancarlo
dc.contributor.authorGargantilla, Marta
dc.contributor.authorPriego, Eva-María
dc.contributor.authorCarmona, Álvaro
dc.contributor.authorPassarella, Daniele
dc.contributor.authorScrepanti, Isabella
dc.contributor.authorBotta, Bruno
dc.contributor.authorPriego, Eva-María
dc.contributor.authorCarmona, Álvaro
dc.contributor.authorPassarella, Daniele
dc.contributor.authorScrepanti, Isabella
dc.contributor.authorBotta, Bruno
dc.contributor.authorPalermo, Rocco
dc.contributor.authorMori, Mattia
dc.contributor.authorGhirga, Francesca
dc.date.accessioned2026-01-21T12:05:54Z
dc.date.available2026-01-21T12:05:54Z
dc.date.issued2019-02-26
dc.identifier.citationQuaglio, D., Zhdanovskaya, N., Tobajas, G., Cuartas, V., Balducci, S., Christodoulou, M. S., Fabrizi, G., Gargantilla, M., Priego, E. M., Carmona Pestaña, Á., Passarella, D., Screpanti, I., Botta, B., Palermo, R., Mori, M., Ghirga, F., & Pérez-Pérez, M. J. (2019). Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia. ACS medicinal chemistry letters, 10(4), 639–643. https://doi.org/10.1021/acsmedchemlett.8b00608es
dc.identifier.issn1948-5875
dc.identifier.urihttps://hdl.handle.net/20.500.12412/7040
dc.description.abstractBased on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.es
dc.language.isoenges
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleChalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T‑cell Acute Lymphoblastic Leukemiaes
dc.typearticlees
dc.identifier.doi10.1021/acsmedchemlett.8b00608
dc.issue.number4es
dc.journal.titleACS Medicinal Chemistry Letterses
dc.page.initial639es
dc.page.final643es
dc.rights.accessRightsopenAccesses
dc.subject.keywordChalconees
dc.subject.keywordtetrahydronaphthalene scaffoldes
dc.subject.keywordNotch inhibitorses
dc.subject.keywordT-ALLes
dc.subject.keywordcanceres
dc.volume.number10es


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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