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Generation of a human control iPSC line with a European mitochondrial haplogroup U background

Author:
Galera-Monge, Teresa; Zurita-Díaz, Francisco; González-Páramos, Cristina; Moreno-Izquierdo, Ana; Fraga, Mario F.; [et al.]
URI:
https://hdl.handle.net/20.500.12412/7085
ISSN:
1873-5061
DOI:
10.1016/j.scr.2015.12.010
Date:
2016-01-10
Keyword(s):

Defects of intergenomic communication

Induced pluripotent stem cells

iPSC

iPS cells

POLG

Abstract:

Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

Human iPSC line N44SV.5 was generated from primary normal human dermal fibroblasts belonging to the European mitochondrial haplogroup U. For this purpose, reprogramming factors Oct3/4, Sox2, Klf4, and cMyc were delivered using a non-integrative methodology that involves the use of Sendai virus.

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